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Updated: Sep 23, 2026

Unilateral Lung Volume Analysis Using Micro-CT for Enhanced Assessment of Pulmonary Fibrosis in Preclinical Models
Published on: June 20, 2025
[Lung contusion: relevance of initial injured pulmonary volume measurement by computed tomography]
F Christin1, N Meyer, A Launoy
1Département d'anesthésie-réanimation-Samu, hôpital Edouard-Herriot, place d'Arsonval, 69437 cedex 03, Lyon, France. Christin.Francoise@wanadoo.fr <Christin.Francoise@wanadoo.fr>
Objective:
To evaluate computed tomography quantification of injured pulmonary volume after thoracic trauma and its relevance for severity grade of patients with lung contusion.
Study Design:
Retrospective study in a major French Level I university trauma center.
Patients And Methods:
Clinical and biological data including oxygenation index (PaO2/FIO2) and therapeutics modalities during the first 5 days: positive end expiratory pressure (Peep) and nitric oxide (NO), were collected on 49 patients with lung contusion resulting from thoracic trauma. Injured pulmonary volume was evaluated on initial thoracic tomodensitometry by 2 senior radiologists. The correlation between oxygenation index, therapeutics modalities and initial injured pulmonary volume was assessed for signification.
Results:
Injured pulmonary volume larger than 37.75% of total lung volume is associated with both hypoxemia at the twenty-fourth hour (PaO2/FIO2 <300), and need for Peep >6 cm H2O and /or ongoing NO administration on day 5.
Conclusion:
Injured parenchymal pulmonary volume evaluation on initial tomodensitometry seems to be an important indicator of lung contusion severity. Thoracic computed tomography provides additional prognostic information in the initial evaluation of thoracic trauma with parenchymal injury.
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