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Related Experiment Videos

Quinidine photosensitivity.

D M Pariser, J R Taylor

    Archives of Dermatology
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Photosensitive dermatitis from quinidine sulfate cleared upon drug withdrawal and reappeared with reintroduction. Ultraviolet-A (UV-A) light reproduced the reaction in affected patients, indicating an idiosyncratic photosensitivity to quinidine.

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    Area of Science:

    • Dermatology
    • Photobiology
    • Pharmacology

    Background:

    • Photodermatitis is a skin reaction triggered by sunlight exposure.
    • Quinidine sulfate is a medication used to treat cardiac arrhythmias.
    • Drug-induced photosensitivity can manifest as various skin reactions upon light exposure.

    Observation:

    • Three patients developed photodermatitis while taking oral quinidine sulfate.
    • The dermatitis resolved upon discontinuation of quinidine and recurred upon its reintroduction.
    • Experimental exposure to long-wave ultraviolet light (UV-A) reproduced the dermatitis in these patients.

    Findings:

    • Patients with quinidine-induced photodermatitis showed a decreased minimal erythema dose (MED) to UV-A irradiation.
    • Individuals taking quinidine without dermatitis had normal MEDs and UV-A responses.

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  • Normal subjects did not react to intradermal quinidine injection followed by UV-A irradiation.

    • Implications:

    • The photosensitive dermatitis associated with quinidine appears to be an idiosyncratic reaction.
    • Ultraviolet-A (UV-A) light plays a significant role in the development of this quinidine-induced photosensitivity.
    • Quinidine should be recognized as a potential causative agent for photosensitive dermatitis.