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Myelogenous leukemia cutis resembling stasis dermatitis
Howard Y Chang1, Kerry M Wong, Marcus Bosenberg
1Division of Dermatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Journal of the American Academy of Dermatology
|July 2, 2003
Summary
Leukemia cutis can mimic inflammatory skin conditions. In myelodysplastic syndrome, it presented as tender brown plaques, initially mistaken for stasis dermatitis.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Leukemia cutis (LC) is a rare manifestation of leukemia.
- LC can present with diverse clinical features, often mimicking benign dermatological conditions.
- Early recognition is crucial for appropriate management.
Observation:
- A patient with myelodysplastic syndrome (MDS) developed an acute eruption of lesions.
- The lesions were bilateral, lower-extremity, tender, indurated, brown plaques.
- Clinically, the presentation strongly suggested chronic stasis dermatitis.
Findings:
- Histopathological examination revealed a dermal leukemic infiltrate.
- The infiltrate consisted of myeloblasts, confirming leukemia cutis.
- This finding distinguished it from the suspected inflammatory dermatosis.
Implications:
- This case highlights the importance of considering leukemia cutis in the differential diagnosis of atypical skin lesions.
- Myelodysplastic syndrome can present with cutaneous manifestations that mimic common dermatoses.
- Prompt diagnosis through biopsy is essential for patients with suspected leukemia cutis.