Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Surface modification of PLGA microspheres.

M Müller1, J Vörös, G Csúcs

  • 1Laboratory for Surface Science and Technology, Department of Materials, Swiss Federal Institute of Technology, ETH-Zürich, Switzerland.

Journal of Biomedical Materials Research. Part A
|July 2, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental Observation of the Motion of Ions in a Resonantly Driven Plasma Wakefield Accelerator.

Physical review letters·2025
Same author

Visualization of Pulpal Structures by SWIR in Endodontic Access Preparation.

Journal of dental research·2024
Same author

Filamentation of a relativistic proton bunch in plasma.

Physical review. E·2024
Same author

Correction to: Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners.

European journal of applied physiology·2021
Same author

Ca<sup>2+</sup> signalling is critical for autoantibody-induced blistering of human epidermis in pemphigus.

The British journal of dermatology·2021
Same author

Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners.

European journal of applied physiology·2021
Same journal

Biomimetic Collagen Scaffolds Natural Cross-Linking Strategies via Transglutaminase and Methylglyoxal for Skin Repair.

Journal of biomedical materials research. Part A·2026
Same journal

Granular Hydrogel Composites for Noninvasive Optical Biosensing.

Journal of biomedical materials research. Part A·2026
Same journal

Performance Evaluation of Highly Uniform Astragalus Polysaccharide/Silk Fibroin Microspheres Fabricated via Microfluidics as Biodegradable Fillers: Collagen Regeneration and Tissue Reaction.

Journal of biomedical materials research. Part A·2026
Same journal

Combining Supramolecular and Covalent Chemistry to Form Reinforced Fibrillar Network Hydrogels From Fibrinogen Derivatives.

Journal of biomedical materials research. Part A·2026
Same journal

Bioactive-Loaded Detachable Crosslinked Hyaluronic Acid Microneedles: Structural Validation and Clinical Anti-Wrinkle Efficacy.

Journal of biomedical materials research. Part A·2026
Same journal

Tunable Sol-Gel Transition in Poloxamer Blends for Injectable Osteoarticular Applications.

Journal of biomedical materials research. Part A·2026
See all related articles

Poly(L-lysine)-g-poly(ethylene glycol) (PLL-g-PEG) coatings significantly reduce protein adsorption on poly(lactic-co-glycolic acid) (PLGA) microspheres. This innovation enables functionalizable, low protein-binding microspheres for advanced drug delivery and biosensor applications.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Poly(lactic-co-glycolic acid) (PLGA) microspheres are promising for drug delivery due to biocompatibility and biodegradability.
  • Nonspecific protein adsorption onto PLGA surfaces limits targeted drug delivery efficacy.
  • Poly(L-lysine)-g-poly(ethylene glycol) (PLL-g-PEG) is known to reduce protein adsorption on other surfaces.

Purpose of the Study:

  • To evaluate the protein-repellent properties of PLL-g-PEG coatings on PLGA microspheres.
  • To demonstrate the feasibility of creating functionalizable PLGA microspheres using PLL-g-PEG.
  • To establish a basis for improved drug delivery and biosensor design.

Main Methods:

  • Coating PLGA microspheres with PLL-g-PEG.

Related Experiment Videos

  • Utilizing confocal laser scanning microscopy (CLSM) for semiquantitative protein adsorption analysis.
  • Characterizing the introduction of functional groups via functionalized PLL-g-PEG.

    • Main Results:

    • PLL-g-PEG coatings were successfully introduced onto PLGA microspheres, allowing for functionalization.
    • PLL-g-PEG coated microspheres exhibited a significant reduction in adsorbed proteins, by two orders of magnitude, compared to uncoated PLGA microspheres.
    • The study confirmed the protein-repellent efficacy of PLL-g-PEG on PLGA microspheres.

    Conclusions:

    • PLL-g-PEG coatings effectively minimize protein adsorption on PLGA microspheres.
    • Functionalizable, low protein-binding microspheres are achievable using this approach.
    • These microspheres offer a foundation for developing advanced drug delivery systems and biosensors.