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Related Experiment Video

Updated: Jul 2, 2026

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

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Tunable Sol-Gel Transition in Poloxamer Blends for Injectable Osteoarticular Applications.

Marta Tuszynska1, Joanna Skopinska-Wisniewska2, Kaoutar Chattahy3,4

  • 1Department of Oncology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.

Journal of Biomedical Materials Research. Part A
|July 1, 2026
PubMed
Summary

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This summary is machine-generated.

Blends of thermoresponsive poloxamers offer tunable properties for injectable therapies. Optimized poloxamer hydrogels show promise for meniscal and joint repair, demonstrating good biocompatibility and controlled gelation.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Thermoresponsive poloxamers are crucial for biomedical applications.
  • Controlling sol-gel transition near body temperature is key for translational success.

Purpose of the Study:

  • Evaluate poloxamer blends for injectable meniscal and joint therapies.
  • Characterize rheological properties, gelation, injectability, and biocompatibility.

Main Methods:

  • Formulation of poloxamer blends (Synperonic F-108, Kolliphor K 407, Poloxamer 188).
  • Rheological analysis and temperature-dependent gelation measurements.
  • In vitro assessment of injectability, cell viability, and fibrochondrocyte response.

Main Results:

Keywords:
Pluronicbiomaterialsinjectmeniscitear

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Last Updated: Jul 2, 2026

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
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  • Synperonic F-108/Poloxamer 188 blends showed reduced adhesion and maintained cell viability.
  • Kolliphor K 407/Poloxamer 188 blends formed stable gels at body temperature with favorable biological responses.
  • Tailoring poloxamer composition allows for adjustable thermoresponsive behavior and material properties.

Conclusions:

  • Optimized poloxamer blends can be designed for specific biomedical functions.
  • These hydrogels are suitable for injectable osteoarticular repair and drug delivery systems.
  • Adjustable thermoresponsive behavior and biocompatibility support their clinical potential.