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Biological Augmentation of Meniscal Repair: A Review with Insights into Injectable Hydrogel Delivery
Marta Tuszynska1, Joanna Skopinska-Wisniewska2, Anna Bajek1
1Department of Oncology, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun, Lukasiewicza 1 St., 85-821 Bydgoszcz, Poland.
Gels (Basel, Switzerland)
|October 28, 2025
Summary
Biologically active therapies like platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) show promise for enhancing meniscal healing and preserving joint tissue. Further research is needed to optimize these treatments, particularly within injectable hydrogel systems.
Area of Science:
- Orthopedics
- Regenerative Medicine
- Biomaterials Science
Background:
- Meniscal injuries frequently cause chronic pain, joint instability, and increase osteoarthritis risk.
- Conventional treatments like partial meniscectomy can accelerate joint degeneration.
- Biologically active therapies offer novel approaches to meniscal repair.
Purpose of the Study:
- To review the efficacy of various biological agents in promoting meniscal healing.
- To assess the potential of integrating these agents into injectable hydrogel systems for minimally invasive delivery.
- To analyze recent literature (2015-2025) on biological agents and biomaterials for meniscal repair.
Main Methods:
- Systematic review of recent scientific literature (2015-2025).
- Evaluation of platelet-rich plasma (PRP), mesenchymal stem cells (MSCs), hyaluronic acid (HA), bone marrow aspirate concentrate (BMAC), collagen, growth factors (GFs), and silk fibroin (SF).
- Focus on injectable hydrogel systems for targeted delivery.
Main Results:
- PRP, MSCs, and HA demonstrate significant potential in modulating inflammation and promoting tissue regeneration.
- Biological therapies offer less invasive alternatives supporting tissue preservation, though not replacing surgery for complex tears.
- Injectable hydrogel systems show promise for targeted, minimally invasive delivery of these agents.
Conclusions:
- Biologically active agents represent promising strategies for enhancing meniscal repair and mitigating osteoarthritis progression.
- Hydrogel-based delivery systems offer a viable platform for targeted and minimally invasive application of these regenerative therapies.
- Further long-term clinical research is crucial to validate efficacy, standardize protocols, and optimize hydrogel formulations for meniscal healing.
