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Conceptualization and Preliminary Characterization of Poloxamer-Based Hydrogels for Biomedical Applications
Marta Tuszynska1, Joanna Skopinska-Wisniewska2, Mateusz Bartniak3
1Nicolaus Copernicus University in Torun, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Faculty of Oncology, Lukasiewicza 1 St., Bydgoszcz 85-094, Poland.
Bioconjugate Chemistry
|May 19, 2025
Summary
This study explored poloxamer hydrogels for treating meniscus tears. Certain poloxamer mixtures show promise as injectable systems for musculoskeletal injuries and osteoarticular regeneration.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Regenerative Medicine
Background:
- Poloxamers are triblock copolymers with thermosensitive sol-gel properties crucial for biomedical applications.
- Optimizing poloxamer formulations is key for effective use in treating conditions like meniscus tears.
Purpose of the Study:
- To evaluate three poloxamer mixtures for their suitability in treating meniscus tears.
- To assess gel formation, injectability, and cell compatibility of poloxamer hydrogels.
- To determine the influence of poloxamer concentration and composition on their biomedical potential.
Main Methods:
- Rheological property analysis to determine gelation and viscosity.
- Cytotoxicity assessments using NIH/3T3 fibroblast cells.
- Cellular migration experiments to evaluate cell compatibility.
Main Results:
- Poloxamer hydrogels demonstrated suitable properties for injectable systems and drug delivery.
- A mixture of Synperonic F108 and Poloxamer 188 showed good cell viability and potential as a matrix or coating.
- A Kolliphor 407 and Poloxamer 188 combination exhibited enhanced viscosity and maintained a gel state at physiological temperature, indicating biocompatibility.
Conclusions:
- Poloxamer concentration and composition significantly impact their suitability for biomedical applications.
- These triblock copolymer systems possess favorable sol-gel transition kinetics and biocompatibility for surgical applications.
- The evaluated poloxamer mixtures show potential for osteoarticular regeneration and treating musculoskeletal injuries.
