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Genetic sequence data for pharmacogenomics.

Russ B Altman¹

¹Stanford Medical Informatics, Department of Genetics, 251 Campus Drive MSOB X-215, Stanford, CA 94305-5479, USA. russ.altman@stanford.edu

Current Opinion in Drug Discovery & Development

|July 2, 2003

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Pharmacogenetics studies how gene variations affect drug responses. Pharmacogenomics uses large-scale genomic data, like DNA sequencing, to identify these variations in important drug-related genes.

Area of Science:

Genomics
Pharmacology
Genetics

Background:

Pharmacogenetics investigates genetic influences on drug efficacy and toxicity.
Pharmacogenomics applies large-scale genomic techniques to pharmacogenetics.
High-throughput DNA sequencing is central to identifying genetic variations.

Purpose of the Study:

To outline the scope and methods of pharmacogenomics.
To highlight the importance of genetic variations in drug response.
To establish baseline measurements of sequence variation in pharmacologically relevant genes.

Main Methods:

Utilizing high-throughput DNA sequencing.
Conducting systematic surveys of genetic variation.
Analyzing coding and promoter regions of genes.

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Main Results:

Identification of sequence variations in pharmacologically important genes.
Establishment of reliable baseline measurements for genetic variation.
Foundation laid for population frequency determination and association studies.

Conclusions:

Pharmacogenomics is advancing the understanding of genotype-phenotype relationships in drug response.
Systematic genetic variation surveys are crucial for personalized medicine.
Future research will focus on linking genetic data to clinical drug outcomes.