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Bioactive glass-polymer materials for controlled release of ibuprofen
S Ladrón de Guevara-Fernández1, C V Ragel, M Vallet-Regí
1Facultad de Farmacia, Departamento de Química Inorgánica y Bioinorgánica, Universidad Complutense, Madrid 28040, Spain.
Abstract:
The ibuprofen (IB) release from samples composed by SiO2-CaO-P2O5 bioactive glass, poly-L-lactic acid (PLA), and polymethylmethacrylate (PMMA) has been studied. Data showed a fast anti-inflammatory drug release during the first 8h when these polyphasic materials are soaked in simulated body fluid (SBF). The analysis of the samples before and after different soaking periods in SBF demonstrates the growth of an apatite-like layer on the materials surface. The IB release rate is related with the growth kinetics of this layer, that is slower when the materials do not contain the biodegradable polymer PLA. On the other hand, different IB and/or glass contents do not affect the in vitro behavior of these materials.