Related Experiment Video
Updated: Mar 10, 2026

Generating Whole Bacterial Genomes from Clinical Samples using a Target Enrichment Workflow
Published on: August 15, 2025
DNA probability profiles: examples from the Treponema pallidum genome
1Department of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA. poland@jhu.edu
Abstract:
In this paper we apply an algorithm developed by Poland (Biopolymers 13 (1974) 1859) to treat the statistical mechanics of the thermal unwinding of DNA to the genome of Treponema pallidum, the syphilis spirochete. We calculate probability profiles (giving the probability that each unit in the molecule is in the helix-state) and other statistical distributions for genes and sequences of genes, the longest containing 100 genes and 107,139 base pairs (approximately 10% of the genome).
More Related Videos
Related Concept Videos
DNA Bacteriophages
Modern Molecular Taxonomy

