Stereoselective synthesis of 1'-C-carbon-subsituted 4'-thionucleosides from 4-thiofuranoid glycal
K Haraguchi1, H Takahashi, H Tanaka
1School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo 142-8555, Japan.
Nucleic Acids Research. Supplement (2001)
|July 3, 2003
Abstract:
PhSeCl or NIS-initiated glycosylation to 2-5, which were prepared through lithiation of 4-thiofuranoid glycal 1, proceeded stereoselectively to give the target 1'-C-carbon-substituted 4'-thiopyrimidine nucleosides. This synthetic method enabled us to synthesize 4'-thioanalogue 13 of nucleoside antibiotic angustmycin.
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