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Updated: Jul 31, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Synthesis of small multifunctional molecules having nucleic acid binding property
K Nakanuma1, T Moriguchi, H Suzuki
1Department of Chemistry, Faculty of Engineering, Gunma University, Tenjin-cho, Kiryu, Gunma 376-8515, Japan.
Abstract:
We have previously reported that a multifunctional conjugate having the acridine derivative as an intercalative molecule and the polyamine moiety as an RNA cleaving molecule bound to a double helical RNA and cleaved the target efficiently. Along the study to develop a sequence and site specific artificial RNA cleaving molecule, we have development a novel intercalative molecule having polyamine moiety and DNA connecting function. The trisamine-acridine-tethered DNA is expected to bind to the complementary RNA and cleave the phosphodiester bond of the RNA near the position of the built-in interecalator.
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