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Synthesis and biological properties of DNA-peptide conjugates
1Department of Environmental and Biological Chemistry, Kyushu School of Engineering, Kinki University.
Nucleic Acids Research. Supplement (2001)
|July 3, 2003
Abstract:
Some naturally occurring nuclear localizing signals (NLSs) and some artificially designed peptides were covalently conjugated by solid phase fragment condensation (SPFC) method. These DNA-peptide conjugates showed enhanced permeability into cells as well as enhanced hybrid stability with ssDNA and dsDNA, and also higher resistance against nuclease digestion.