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Synthesis and DNA binding properties of alkyl-linked bis(benzimidazole) compounds
1Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi 753-8512, Japan.
Nucleic Acids Research. Supplement (2001)
|July 3, 2003
Abstract:
We have synthesized novel alkyl-linked bis(benzimidazole) compounds and studied their DNA binding properties by spectroscopic (absorption, CD, flow dichroism and fluorescence) and viscosity measurements. The results indicate that bis(benzimidazole) compounds interact with DNA both by intercalation and by groove binding.