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Study on curcumin-oligonucleotide conjugate as a probable anticancer agent: its hybridisation with telomere target
1Nucleic Acids Research Laboratory, Department of Chemistry, University of Allahabad, Allahabad-211 002, India.
Nucleic Acids Research. Supplement (2001)
|July 3, 2003
Abstract:
Curcumin-oligonucleotide conjugate was synthesised by attaching diglycyl conjugate of curcumin to 12-mer complementary telomere sequence 5'-AATCCCAATCCC-3'. An enhanced Tm of 6 degrees C was found, showing high affinity for the target strand. This may be exploited for the suppression of cancer i.e. by blocking the expression of telomere sequence [GGGATT]n repeats.