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Structural transition of d(G4T4G4) from antiparallel to parallel G-quartet induced by divalent cations
D Miyoshi1, A Nakao, N Sugimoto
1Department of Chemistry, Faculty of Science and Engineering, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.
Nucleic Acids Research. Supplement (2001)
|July 3, 2003
Abstract:
We obtained thermodynamic parameters of an antiparallel G-quartet formation of d(G4T4G4) with 1 mM divalent cation (Mg2+, Ca2+, Mn2+, Co2+, or Zn2+). In addition, we also found that a higher concentration of a divalent cation induced a transition from an antiparallel to a parallel G-quartet structure. These results indicate that the divalent cations are a good tool for regulating the G-quartet structures and their stability.