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Linker chain effect of ferrocenyl naphthalene diimide on a double stranded DNA preference
S Sato1, H Takamiya, K Yamashita
1Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
Nucleic Acids Research. Supplement (2001)
|July 3, 2003
Abstract:
Naphthalene diimide derivative 1 carrying two 3-(ferrocenyl-methylamino)-propyl substituents was synthesized as a new hybrid indicator for electrochemical gene sensing. Ligand 1 showed a preference for double stranded DNA four-times larger than 2 previously described. The peak potential of 1 shifted 30 mV toward the negative side from that of 2, thereby shortening the time required for gene detection.