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Functional genomics and proteomics: charting a multidimensional map of the yeast cell
Gary D Bader1, Adrian Heilbut, Brenda Andrews
1Computational Biology Center, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 460, 10021, New York, NY, USA.
Trends in Cell Biology
|July 3, 2003
Summary
Functional genomics projects aim to map cellular components, including gene expression and protein data. Bioinformatics tools help analyze this complex data for new discoveries in yeast.
Area of Science:
- Molecular Biology
- Genomics
- Proteomics
- Bioinformatics
Background:
- Large-scale functional genomics requires comprehensive cellular mapping.
- Budding yeast data is partially assembled, offering insights.
- Current data facilitates connections between cellular events and hypothesis generation.
Purpose of the Study:
- To review genomics and proteomics technologies.
- To describe bioinformatics methods for data exploration.
- To foster new discoveries in functional genomics.
Main Methods:
- Review of various genomics technologies.
- Review of various proteomics technologies.
- Description of bioinformatics approaches for data analysis.
Main Results:
- Functional genomics data is being assembled for budding yeast.
- Existing data allows for the forging of connections between cellular events.
- Numerous hypotheses are being generated from functional genomics data.
Conclusions:
- Comprehensive cellular mapping is a key challenge in functional genomics.
- Bioinformatics is crucial for exploring and interpreting large-scale functional genomics data.
- Continued research in genomics and proteomics will advance our understanding of cellular function.