Related Experiment Video

Updated: Sep 23, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Anti-beta2-glycoprotein I antibodies and ischemic stroke in a 20-month-old boy

Eustathia Katsarou1, Achilleas Attilakos, Smaragdi Fessatou

  • 1Department of Neurology, Panagiotis and Aglaïa Kyriakou Children's Hospital, Athens, 11527 Greece. pectasid@otenet.gr

Pediatrics
|July 3, 2003
PubMed

Insights

This study reports the first case of childhood ischemic stroke linked solely to antibodies to beta2-glycoprotein I (anti-beta2GPI), even when standard antiphospholipid tests were negative. It highlights the importance of testing for anti-beta2GPI in children with suspected antiphospholipid syndrome.

Area of Science:

  • Pediatric Neurology
  • Immunology
  • Vascular Medicine

Background:

  • Antibodies to beta2-glycoprotein I (anti-beta2GPI) are linked to thrombosis and pregnancy issues.
  • The prevalence of anti-beta2GPI in pediatric cerebral infarction is not well-established.
  • Antiphospholipid syndrome (APS) is a significant cause of stroke in children.

Observation:

  • A 20-month-old boy experienced an ischemic stroke.
  • High immunoglobulin G anti-beta2GPI titers were detected.
  • Standard antiphospholipid assays, including anticardiolipin antibodies and lupus anticoagulant tests, were negative.
  • Other causes of cerebral infarction were ruled out.

Findings:

  • This case represents the first documented instance of childhood ischemic stroke associated exclusively with anti-beta2GPI.
  • The patient demonstrated persistently high anti-beta2GPI IgG levels over two years.
  • Treatment with low-dose aspirin was initiated.

Implications:

  • This case underscores the necessity of screening for anti-beta2GPI in pediatric patients with suspected APS, especially when conventional antiphospholipid antibody tests are negative.
  • It supports broader diagnostic criteria for APS in children presenting with ischemic events.
  • Early detection and management of anti-beta2GPI-associated conditions can potentially prevent recurrent thrombotic events in children.

More Related Videos

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke09:00

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

Published on: February 10, 2023

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...