Real-time detection of vessel diameters with ultrasound

Transcutaneous vessel imaging is a frequently used ultrasound imaging modality in medicine. The measurement of vessel diameters can be done with conventional B-mode imaging systems, which work at frame rates up to 100 Hz. Furthermore, there are special systems available, which can track vessel walls very precisely using the phase of signals that are sent at frame rates up to several thousand Hz. Though, such systems are usually not able to provide the examiner with 2D images of the object. With respect to brachial artery flow-mediated vasodilatation (FMD), which is frequently used as a measure of endothelial function, it is necessary to observe diameter changes of small arterial vessels noninvasively for several minutes at a high resolution. In the past, the diameter had to be measured manually in tedious postprocessing of ECG-gated image sequences. We developed a system composed of a Siemens Omnia ultrasound system with a VF13-5 transducer (9 MHz center frequency) and a personal computer, that is capable of calculating vessel diameter changes with an accuracy below the wavelength of the ultrasound system in real-time at a frame rate of 27 Hz. We implemented a two-dimensional active contour model using the Viter-bi-algorithm and a phase-sensitive vessel wall tracking algorithm, in order to guarantee both, geometric information and accuracy. Results from carotid and brachial arteries show that arterial pulsations below 0.1 mm can be visualized reliably over several minutes. With this system we want to find out, if FMD is suitable for an individual assessment of the risk for cardiovascular diseases.