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Benzannulation of 3-substituted pyrroles to indoles
Alan R Katritzky1, Stephane Ledoux, Satheesh K Nair
1Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
The Journal of Organic Chemistry
|July 4, 2003
Abstract:
In a new general indole synthesis, the anion derived from benzotriazolyl derivative 5b underwent regioselective 1,4-addition to various alpha,beta-unsaturated ketones; subsequent acid-catalyzed cyclization formed the corresponding indoles 1a-f.