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Hepatic resection for metastatic renal tumors: is it worthwhile?
1Centre Hépato-Biliaire, Hôpital Paul Brousse, Université Paris-Sud, Villejuif, France.
Annals of Surgical Oncology
|July 4, 2003
Summary
Aggressive liver resection for renal tumor metastases offers long-term survival chances, particularly after a lengthy disease-free interval. However, recurrence remains common despite surgical intervention for these liver metastases.
Area of Science:
- Oncology
- Surgical Oncology
- Hepatobiliary Surgery
Background:
- Liver metastases from renal tumors carry a poor prognosis due to limited treatment options.
- Isolated liver metastases from renal tumors are rarely curable with surgery.
- Understanding outcomes for resectable liver metastases is crucial.
Observation:
- Retrospective analysis of 14 patients undergoing liver resection for renal tumor metastases between 1982 and 2001.
- No operative or postoperative mortality observed.
- Median survival of 26 months, with 1-year and 3-year survival rates of 69% and 26% respectively.
Findings:
- Curative hepatectomy, disease-free interval >24 months post-nephrectomy, tumor size <50 mm, and repeat hepatectomy for recurrence were associated with improved survival.
- Patients achieving curative resection had a 2-year survival of 69% versus 0% for non-curative.
- Long-term survival was achieved in 4 patients, with one experiencing recurrence.
Implications:
- An aggressive surgical approach for eradicating renal tumor liver metastases can lead to long-term survival.
- A significant disease-free interval post-nephrectomy is a key factor for better outcomes.
- Despite aggressive treatment, liver metastases recurrence after resection is frequent, necessitating continued monitoring.