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Related Experiment Videos

Divergence in the spatial pattern of gene expression between human duplicate genes.

Kateryna D Makova1, Wen-Hsiung Li

  • 1Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA.

Genome Research
|July 4, 2003
PubMed
Summary

Human duplicate genes rapidly diverge in expression patterns, correlating with sequence changes. This suggests protein and spatial expression divergence are initially linked, impacting gene function evolution.

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Area of Science:

  • Evolutionary biology
  • Genomics
  • Molecular evolution

Background:

  • Microarray gene expression data offer insights into molecular evolution.
  • Understanding gene duplication and divergence is crucial for evolutionary studies.

Purpose of the Study:

  • Analyze spatial expression patterns of human duplicate genes.
  • Investigate the relationship between coding sequence divergence and expression divergence.

Main Methods:

  • Utilized oligonucleotide microarray data for human duplicate gene pairs.
  • Calculated synonymous (K(S)) and nonsynonymous (K(A)) divergence.
  • Computed correlation coefficients (R) for expression levels across tissues.

Main Results:

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  • Strong positive correlation found between divergent expression and K(S)/K(A).
  • Human duplicate gene expression divergence appears rapid, potentially faster than yeast.
  • Significant negative correlation between expression level correlation (R) and K(S)/K(A) (for K(A) ≤ 0.2).

    • Conclusions:

    • Protein sequence divergence and spatial expression pattern divergence are initially coupled in human duplicate genes.
    • Rapid divergence in spatial expression impacts gene function.
    • Gene expression divergence evolves quickly in human duplicate genes.