Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxygen delivery in irradiated normal tissue.

Mohammad F Kiani1, Ramin Ansari, M Waleed Gaber

  • 1School of Biomedical Engineering, University of Tennessee Health Science Center, Memphis, TN 38163, USA. mkiani@utmem.edu

Journal of Radiation Research
|July 5, 2003
PubMed
Summary

Ionizing radiation alters microvascular networks. While oxygen delivery remains unchanged, tissue oxygenation patterns differ, suggesting late radiation effects stem from factors beyond oxygen supply.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dysregulation of Neutrophil-Endothelial Communication in Sepsis: Mechanisms and Therapeutic Perspectives.

Cells·2026
Same author

Anti-CSF-1R therapy with combined immuno-chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched triple negative breast cancers.

Nature communications·2026
Same author

Giant osteoid osteoma of mandible in a 24-year-old female: a case report.

Journal of medical case reports·2025
Same author

Adrenomedullin overexpression protects mice from experimental bronchopulmonary dysplasia and associated pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology·2025
Same author

Prioritizing FDA approved therapeutics for treating sepsis phenotypes: A network modeling approach based on neutrophil proteomics.

Frontiers in immunology·2025
Same author

Coordinated regulation by lncRNAs results in tight lncRNA-target couplings.

Cell genomics·2025

Area of Science:

  • Physiology
  • Radiation Biology
  • Biomedical Engineering

Background:

  • Ionizing radiation disrupts microvascular networks, impacting tissue oxygen delivery.
  • Understanding these changes is crucial for managing late radiation effects in normal tissues.

Purpose of the Study:

  • To investigate microvascular network alterations post-irradiation.
  • To model the impact of these changes on tissue oxygen delivery.
  • To identify the causes of late microvascular effects after radiation exposure.

Main Methods:

  • Utilized a hamster cremaster muscle model for experimental observations.
  • Employed a mathematical model to simulate microhemodynamic and oxygen delivery changes.
  • Measured microvascular parameters and tissue oxygenation patterns at various time points post-irradiation.

Related Experiment Videos

Main Results:

  • Irradiation significantly affected parameters like red blood cell (RBC) transit time, but not RBC path length up to 180 days.
  • Mathematical modeling revealed significantly different tissue oxygenation patterns in irradiated tissue starting 3 days post-irradiation.
  • Despite altered oxygenation patterns, overall oxygen delivery to irradiated tissue was not significantly different from controls between 7 days and 6 months.

Conclusions:

  • Microvascular late effects in irradiated normal tissue may arise from mechanisms independent of compromised tissue oxygenation.
  • Tissue oxygenation patterns are altered early after irradiation, but compensatory mechanisms may maintain overall oxygen delivery.
  • Further research is needed to elucidate the specific factors contributing to late radiation-induced microvascular damage.