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Diverse motifs of mannoside clustering on a beta-cyclodextrin core
Fernando Ortega-Caballero1, Juan J Giménez-Martínez, Antonio Vargas-Berenguel
1Area de Química Orgánica, Universidad de Almería, E-04120 Almería, Spain.
Organic Letters
|July 5, 2003
Abstract:
[reaction: see text] A new method for the synthesis of beta-cyclodextrin-based cluster mannosides by application of the Sonogashira cross-coupling reaction is described. The method allows for the persubstitution of the beta-cyclodextrin at either 2- and 3-positions to give two types of heptavalent clusters, at both 2- and 6-positions to give clusters with 14 mannopyranoside units and at 2-, 3-, and 6-positions to obtain clusters with 21 mannopyranoside ligands.