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Copper reagents: a new and efficient solution for the selective addition of metallated propargylic amines to
Frederic Bernaud1, Emmanuel Vrancken, Pierre Mangeney
1UMR 7611-Laboratoire de Chimie Organique, Université Pierre et Marie Curie, 4 Place Jussieu, F-75252, Paris, Cedex 05, France.
Organic Letters
|July 5, 2003
Abstract:
[reaction: see text] Anti alpha-amino-homopropargylic alcohols are prepared by addition of metallated propargylic amines to aldehydes. Among the four organometallic (LI, Zn, Ti, Cu) derivatives used, the most effective are the copper reagents.