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Updated: Sep 23, 2026
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Simultaneous detection of some drugs of abuse in saliva samples by SPME technique
Nadia Fucci1, Nadia De Giovanni, Marcello Chiarotti
1Laboratorio di Tossicologia Forense, Istituto di Medicina Legale e delle Assicurazioni, Università Cattolica del Sacro Cuore, L. go Francesco Vito, 00168-Rome, Italy. fortox@rm.unicatt.it
Abstract:
A simple method for the simultaneous determination of many drugs of abuse in saliva is referred [methadone, 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium perchlorate (EDDP), cocaine, cocaethylene, amphetamine, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyethyl amphetamine (MDEA), N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), cannabidiol (CBD), Delta(9)-tetrahydrocannabinol (THC), cannabinol (CBN)]. Head space-solid phase microextraction (HS-SPME) and direct immersion-solid phase microextraction (DI-SPME) followed by gas chromatographic/mass spectrometric analyses (GC/MS) were employed, and results obtained with both techniques are discussed. The method was validated testing reproducibility, sensitivity, linearity.
