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[Adverse cutaneous reaction to celecoxib: 6 cases]
Annales De Dermatologie Et De Venereologie
|July 5, 2003
Summary
Adverse cutaneous reactions to celecoxib, a non-steroidal anti-inflammatory drug, typically present as mild maculo-papular exanthema and facial edema. While reactions are more frequent than with other NSAIDs, severe cases are rare.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Medicine
Background:
- Investigating adverse cutaneous reactions to celecoxib, a novel non-steroidal anti-inflammatory drug (NSAID).
- Assessing the incidence and characteristics of skin reactions associated with celecoxib use.
Observation:
- Retrospective analysis of 6 patients experiencing cutaneous adverse events.
- Reactions occurred after a mean of 10.2 days for new users and 48 hours for a re-exposed patient.
- Common manifestations included fever, maculo-papular exanthema, facial edema, and occasional mucosal or blistering lesions.
Findings:
- Celecoxib-induced skin reactions were deemed highly probable (I3) in all cases.
- Biological abnormalities were minor and transient in most patients.
- Adverse reaction rates for celecoxib (7.5%) appear higher than for other NSAIDs (4.1%).
Implications:
- Celecoxib-associated cutaneous reactions are generally not severe, contrasting with some other NSAIDs.
- A history of sulfonamide allergy may warrant caution, though direct cross-reactivity is not proven.
- Understanding these reactions is crucial for safe celecoxib prescribing and patient monitoring.
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