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[Dapsone-induced sensory peripheral neuropathy].

L Méry1, H Dega, C Prost

  • 1Service de Dermatologie I, Hôpital Saint-Louis, 75010 Paris.

Annales De Dermatologie Et De Venereologie
|July 5, 2003
PubMed
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Dapsone, a medication for linear IgA dermatosis, can cause peripheral neuropathy. This rare side effect typically resolves after discontinuing dapsone treatment.

Area of Science:

  • Dermatology
  • Neurology

Background:

  • Dapsone is a medication used to treat various dermatological conditions.
  • Peripheral neuropathy is a known, albeit rare, complication associated with dapsone therapy.

Observation:

  • A case study involving a 74-year-old woman with linear IgA dermatosis treated with dapsone.
  • The patient developed sensory peripheral neuropathy one month after initiating dapsone therapy.
  • Neuropathy symptoms resolved within 24 hours of dapsone discontinuation.

Findings:

  • Dapsone-induced peripheral neuropathy is a rare adverse effect.
  • Previously reported cases include motor or mixed neuropathies.
  • Recovery from dapsone-induced neuropathy typically occurs within a year of treatment cessation.

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Implications:

  • Clinicians should be vigilant for peripheral neuropathy in patients treated with dapsone.
  • Early recognition and discontinuation of dapsone can lead to symptom resolution.
  • This case adds to the literature on dapsone's potential neurological complications.