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[Nasal NK/T lymphoma. A case report].

Saloua Ladeb1, Philippe Gaulard, Tarek Ben Othmen

  • 1Centre National de Greffe de Moelle Osseuse, rue Jebel Lakhdar, 1006 Bab Saadoun, Tunis, Tunisie.

Annales De Pathologie
|July 5, 2003
PubMed
Summary

This case study details a nasal NK/T cell lymphoma diagnosis in a 42-year-old man, initially misdiagnosed as chronic sinusitis. The aggressive tumor, linked to Epstein-Barr virus, progressed rapidly.

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Area of Science:

  • Oncology
  • Immunology
  • Pathology

Background:

  • Nasal obstruction can be an initial symptom of rare cancers.
  • Chronic sinusitis may mask or delay the diagnosis of aggressive lymphomas.

Observation:

  • A 42-year-old man presented with a 2-year history of nasal obstruction.
  • Initial biopsy was inconclusive; a second biopsy revealed nasal NK/T cell lymphoma.

Findings:

  • The lymphoma exhibited a pleomorphic lymphoid infiltrate, necrosis, and angiocentric features.
  • Immunohistochemistry and genotypic analysis confirmed Natural Killer (NK) cell origin.
  • Epstein-Barr virus (EBV) infection was identified in neoplastic cells via in situ hybridization.

Implications:

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  • Accurate and timely diagnosis of nasal NK/T cell lymphoma is critical.
  • EBV is implicated in the pathogenesis of this aggressive malignancy.
  • Early detection and treatment strategies are crucial for improving patient outcomes in nasal lymphomas.