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Neurocytoma arising in the pelvis
Nicolaus Friedrichs1, Roland Vorreuther, Hans-Peter Fischer
1Institute of Pathology, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.
Summary
This study reports a rare case of peripheral neurocytoma, a tumor typically found in the brain, located outside the central nervous system. This finding suggests neurocytomas may infrequently occur in peripheral tissues.
Area of Science:
- Neuropathology
- Oncology
Background:
- Central neurocytoma is a rare central nervous system neoplasm characterized by neurocytic differentiation, low proliferative potential, and favorable prognosis.
- Typically found intraventricularly near the foramen of Monro, extraventricular occurrences have been documented.
Observation:
- A 21-year-old male presented with a peripheral neurocytoma located behind the bladder, identified via computed tomography.
- Surgical resection revealed a tumor with histological features of small uniform cells, fibrillarity, and neuropil-like islands.
Findings:
- Immunohistochemistry confirmed neuronal markers (synaptophysin, neuron-specific enolase, neurofilaments) and showed immuno-negativity for vimentin, pan-keratin, desmin, chromogranin, CD-99, and glial fibrillary acidic protein.
- A low proliferation rate (1-2%) was determined, consistent with a low-grade neoplasm.
Implications:
- This represents the second reported case of neurocytoma occurring outside the central nervous system.
- The findings suggest that peripheral neurocytoma, while rare, is a potential diagnosis for tumors in peripheral tissues.