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Tenascin in reactive lymph nodes and in malignant lymphomas
Y Soini1, M Alavaikko, V P Lehto
1Department of Pathology, University of Oulu, Finland.
Pathology, Research and Practice
|December 1, 1992
Summary
Tenascin, an extracellular matrix protein, shows varied distribution in lymphatic tissues and neoplasms. Its accumulation in Hodgkin
Area of Science:
- Immunohistochemistry
- Extracellular Matrix Biology
- Oncology
Background:
- Tenascin is an extracellular matrix protein found in neoplasms.
- Its distribution in lymphatic tissues and lymphomas requires further investigation.
Purpose of the Study:
- To analyze tenascin immunoreactivity in benign and malignant lymphatic lesions.
- To compare tenascin distribution in various lymphomas, including Hodgkin's disease.
Main Methods:
- Immunohistochemical analysis of tenascin in benign lymph nodes, reactive hyperplasias, follicular lymphomas, diffuse lymphomas, and Hodgkin's disease subtypes.
- Evaluation of tenascin immunoreactivity patterns and intensity.
Main Results:
- Faint tenascin immunoreactivity in benign lymph nodes; stronger patterns in reactive hyperplasias.
- Similar tenascin distribution in follicular lymphomas and benign tissues.
- Pronounced tenascin immunoreactivity in specific Hodgkin's disease subtypes (nodular sclerosis, lymphocyte-depletion) within fibrous septa and cords.
Conclusions:
- Tenascin accumulation in lymphoid neoplasms is limited, except in certain Hodgkin's disease subtypes.
- Tumor cells may stimulate fibroblasts to synthesize tenascin.
- Tenascin distribution in lymphatic tissue correlates with reticular fibers.