Related Experiment Video

Updated: Aug 6, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Current and future therapies for ischemic cerebrovascular disease

K Yanaka1, Y Kujiraoka, M Okazaki

  • 1Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.

Drugs of Today (Barcelona, Spain : 1998)
|July 8, 2003
PubMed

Insights

Urgent treatments for ischemic stroke are needed. Recent advances in pharmacological interventions, including tissue plasminogen activator (t-PA) and neuroprotective agents, offer new hope for minimizing brain damage and improving patient outcomes.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Stroke is a leading cause of adult death and disability.
  • Effective treatments for ischemic stroke are urgently required.
  • Current management focuses on acute interventions and managing long-term consequences.

Purpose of the Study:

  • To highlight recent advancements in pharmacological treatments for ischemic stroke.
  • To discuss emerging therapies aimed at minimizing ischemic brain damage.
  • To review strategies for arterial recanalization, neuronal protection, and host response inhibition.

Main Methods:

  • Review of current literature on ischemic stroke treatments.
  • Focus on pharmacologic interventions based on pathophysiologic research.
  • Discussion of tissue plasminogen activator (t-PA) and neuroprotective agents.

Main Results:

  • Tissue plasminogen activator (t-PA) is a key emergent treatment for selected patients within 3 hours of stroke onset.
  • Numerous neuroprotective agents have been developed.
  • New therapies are emerging to potentially reduce ischemic brain damage.

Conclusions:

  • Pharmacological interventions are crucial for managing ischemic stroke.
  • Ongoing research is yielding promising new therapeutic strategies.
  • Advances aim to improve survival and reduce the debilitating effects of stroke.

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice06:54

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...