Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The basement membrane matrix in malignancy.

Jean A Engbring1, Hynda K Kleinman

  • 1Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health/DHHS, 30 Convent Drive, MSC 4370, Bethesda, MD 20892-4370, USA.

The Journal of Pathology
|July 8, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

0.1% RGN-259 (Thymosin ß4) Ophthalmic Solution Promotes Healing and Improves Comfort in Neurotrophic Keratopathy Patients in a Randomized, Placebo-Controlled, Double-Masked Phase III Clinical Trial.

International journal of molecular sciences·2023
Same author

Thymosin β4 and the anti-fibrotic switch

International immunopharmacology·2022
Same author

Hematogenous metastasis and tumor dormancy as concepts or dogma? The continuum of vessel co-option and angiotropic extravascular migratory metastasis as an alternative.

Frontiers in oncology·2022
Same author

Monitoring Angiotropic Extravascular Migratory Metastasis In Vitro.

Methods in molecular biology (Clifton, N.J.)·2022
Same author

Matrigel: history/background, uses, and future applications.

Journal of cell communication and signaling·2021
Same author

Angiotropism, pericytic mimicry and extravascular migratory metastasis: an embryogenesis-derived program of tumor spread.

Angiogenesis·2019

Metastasis, the spread of cancer cells, is a major cause of cancer death. This review examines how laminin, a component of the extracellular matrix, promotes cancer cell metastasis.

Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Cancer metastasis is a leading cause of mortality, responsible for most cancer-related deaths.
  • Tumor cell spread involves a complex cascade of events, including detachment, invasion, and formation of secondary tumors.
  • Understanding metastasis is crucial for developing effective cancer therapies.

Purpose of the Study:

  • To review the metastatic process in cancer.
  • To highlight the role of the extracellular matrix (ECM) in tumor cell metastasis.
  • To specifically examine the impact of laminin on tumor cell behavior during metastasis.

Main Methods:

  • Literature review of studies on cancer metastasis.
  • Analysis of the molecular mechanisms involved in tumor cell invasion and migration.

Related Experiment Videos

  • Focus on the interaction between tumor cells and laminin within the ECM.

    • Main Results:

    • Tumor cell metastasis is a multi-step process requiring cells to detach, invade, and travel to distant sites.
    • The extracellular matrix, particularly laminin, plays a significant role in promoting tumor cell motility and invasion.
    • Laminin facilitates tumor cell adhesion to blood and lymph vessels, aiding in their dissemination.

    Conclusions:

    • Laminin is a key promoter of cancer metastasis.
    • Targeting laminin-ECM interactions may offer a therapeutic strategy to inhibit cancer spread.
    • Further research into the metastatic cascade is essential for improving patient outcomes.