Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prenatal screening for Down syndrome: current and future methods.

Jacob A Canick1, Devereux N Saller, Geralyn M Lambert-Messerlian

  • 1Division of Prenatal and Special Testing, Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA. jcanick@wihri.org

Clinics in Laboratory Medicine
|July 10, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Serum Folate Levels in Reproductive Age Women: Implications for Prevention of Fetal Neural Tube Defects.

Prenatal diagnosis·2025
Same author

Methodological approach for an integrated female-specific study of anxiety and smoking comorbidity.

Frontiers in psychiatry·2023
Same author

Cell-free DNA-based prenatal screening via rolling circle amplification: Identifying and resolving analytic issues.

Journal of medical screening·2023
Same author

Validation of a monoclonal unconjugated estriol antibody for use in prenatal maternal serum screening.

Journal of medical screening·2023
Same author

Surveillance of SARS-CoV-2 Antibodies in Early 2020 among Rhode Island Pregnancies.

Annals of clinical and laboratory science·2022
Same author

Assessment of a Simplified Cell-Free DNA Method for Prenatal Down Syndrome Screening.

Clinical chemistry·2022
Same journal

Advances in Hemostasis Laboratory Testing.

Clinics in laboratory medicine·2026
Same journal

Extracellular Vesicles in Hemostasis.

Clinics in laboratory medicine·2026
Same journal

Thrombin Generation Assay: Ready for Prime Time.

Clinics in laboratory medicine·2026
Same journal

Viscoelastic Testing for the Laboratorian: Recent Advances and Practical Advice.

Clinics in laboratory medicine·2026
Same journal

Practical Recommendations for Harmonization of Hemostasis Testing Across Hospital Sites.

Clinics in laboratory medicine·2026
Same journal

The Role of Hypoxia in Vascular Endothelial Dysfunction and Venous Thromboembolism.

Clinics in laboratory medicine·2026
See all related articles

New prenatal screening methods for Down syndrome offer earlier and safer testing. These advancements significantly reduce the number of women needing invasive diagnostic procedures for birth defect risk assessment.

Area of Science:

  • Maternal-Fetal Medicine
  • Prenatal Diagnostics
  • Genetics

Background:

  • Second-trimester serum screening for Down syndrome has been a standard clinical practice since the mid-1980s.
  • Traditional screening methods identified a significant proportion of pregnant women (up to 1 in 10) at increased risk, often necessitating invasive diagnostic procedures.

Purpose of the Study:

  • To evaluate the evolution and impact of newer prenatal screening strategies for Down syndrome.
  • To highlight the transition towards safer and more accurate noninvasive prenatal testing (NIPT).

Main Methods:

  • Integration of first and second-trimester biochemical markers.
  • Development of screening protocols allowing testing earlier in pregnancy.

Main Results:

Related Experiment Videos

  • Current screening methods identify as few as 1 in 50 to 1 in 100 pregnant women at increased risk.
  • Significant reduction in the false-positive rate compared to older screening protocols.

Conclusions:

  • Improved prenatal screening methods are enhancing safety and accuracy in Down syndrome detection.
  • The ultimate goal is to minimize the need for invasive procedures by refining noninvasive testing.
  • Further advancements are expected to achieve highly accurate noninvasive screening in the near future.