Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basic helix-loop-helix factors in cortical development.

Sarah E Ross1, Michael E Greenberg, Charles D Stiles

  • 1Division of Neuroscience, Children's Hospital, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

Neuron
|July 10, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex.

Science advances·2026
Same author

A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition.

Neuron·2026
Same author

Astrocyte glucocorticoid receptor signalling restricts neuronal plasticity.

Nature·2026
Same author

Genomic approaches for understanding the evolution of the human brain.

Nature neuroscience·2026
Same author

Radiation Oncology-Biology Integration Network: Bridging the Gap between Biological Research and Clinical Practice.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Tegmental kappa-opioid receptor neurons modulate opioid withdrawal via the periaqueductal gray.

Brain : a journal of neurology·2026
Same journal

Fast-conducting mechanonociceptors uniquely engage reflexive and affective pain circuitry to drive protective responses.

Neuron·2026
Same journal

Sparse component analysis: A method that uncovers separable computations within neural population activity.

Neuron·2026
Same journal

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same journal

TGF-β1-induced endothelial transcytosis drives blood-brain barrier leakage during aging.

Neuron·2026
Same journal

Image space opens up for visual neuroscience.

Neuron·2026
Same journal

Septal GLP-1 receptors control alcohol taking and seeking.

Neuron·2026
See all related articles

Basic helix-loop-helix (bHLH) transcription factors are crucial for mammalian neocortex development. They regulate progenitor proliferation, neurogenesis, and the precise timing of cell fate specification, including astrocyte and oligodendrocyte formation.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Basic helix-loop-helix (bHLH) transcription factors play critical roles in mammalian neocortex development.
  • Multipotent cortical progenitors rely on bHLH factors from the Id and Hes families for maintaining proliferation.

Purpose of the Study:

  • To elucidate the specific roles of bHLH transcription factors in regulating key events of mammalian neocortex development.
  • To understand how bHLH factor activity influences progenitor proliferation, neurogenesis, and glial cell fate specification.

Main Methods:

  • The study focuses on analyzing the activity and interplay of various bHLH transcription factor families (Id, Hes, Mash1, Neurogenin1, Neurogenin2, Olig1, Olig2).
  • The research examines the temporal dynamics of bHLH factor activity during different stages of corticogenesis.

Related Experiment Videos

Main Results:

  • A decrease in Hes and Id factors activity, alongside an increase in proneural bHLH factors (Mash1, Neurogenin1, Neurogenin2), drives the transition from proliferation to neurogenesis.
  • Inhibition of proneural bHLH factors in cortical progenitors leads to astrocyte formation.
  • Increased activity of Olig1 and Olig2 bHLH factors, potentially with decreased Id activity, triggers oligodendrocyte formation.

Conclusions:

  • bHLH transcription factors are essential regulators of corticogenesis, controlling the timing of differentiation and cell fate decisions.
  • The precise modulation of bHLH factor activity is fundamental for the proper development of the mammalian neocortex.
  • Understanding bHLH factor dynamics offers insights into neural stem cell regulation and lineage commitment.