The placebo effect in neurological disorders
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Updated: Sep 15, 2026

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
Published on: December 14, 2014
Raúl de la Fuente-Fernández1, Michael Schulzer, A Jon Stoessl
1Pacific Parkinson's Research Centre, University of British Columbia, BC, Vancouver, Canada.
Abstract:
Recent evidence suggests that the placebo effect is mediated by the dopaminergic reward mechanisms in the human brain and that it is related to the expectation of clinical benefit. On the basis of this theory, we propose some criteria for the proper investigation of the placebo effect, and review the evidence for a placebo effect in Parkinson's disease, depression, pain, and other neurological disorders. We also discuss the evidence for the use of placebos in long-term substitution programmes for the treatment of drug addiction.
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