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Related Experiment Videos

Pertussis: an important target for maternal immunization.

Kathryn M Edwards1

  • 1Vice Chair of Clinical Research, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA. kathryn.edwards@mcmail.vanderbilt.edu

Vaccine
|July 10, 2003
PubMed
Summary
This summary is machine-generated.

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Maternal immunization against pertussis in pregnancy can protect newborns. Higher maternal antibodies may weaken infant responses to some vaccines, highlighting the need for timely infant vaccination schedules.

Area of Science:

  • Immunology
  • Pediatrics
  • Vaccinology

Background:

  • Infant pertussis (whooping cough) protection relies on maternal antibodies and early vaccination.
  • Maternal antibodies wane, leaving infants vulnerable before completing their primary immunization series.
  • Understanding the impact of maternal antibodies on infant vaccine response is crucial for optimizing protection.

Purpose of the Study:

  • To quantify antipertussis IgG levels in cord blood and infant serum.
  • To investigate the correlation between maternal antibody concentrations and infant immune response to pertussis vaccines.
  • To evaluate the potential of maternal immunization for neonatal protection.

Main Methods:

  • Measurement of antipertussis IgG concentrations in cord blood and infant serum at various time points.

Related Experiment Videos

  • Assessment of infant antibody responses following whole-cell and acellular pertussis vaccine administration.
  • Statistical analysis to determine associations between maternal antibody levels and infant vaccine responses.

    • Main Results:

    • Cord blood antipertussis IgG levels in infants mirrored maternal levels.
    • Measurable antibodies to pertussis toxin (PT) and filamentous hemagglutinin were absent in most infants by 4 months.
    • Higher maternal PT antibody concentrations correlated with a diminished infant response to whole-cell pertussis vaccine, but not acellular vaccine.

    Conclusions:

    • Maternal immunization during pregnancy may offer passive immunity to newborns.
    • Maternally derived antibodies can potentially interfere with infant responses to certain pertussis vaccine formulations.
    • Maternal immunization could bridge the protection gap until infant vaccination schedules induce robust immunity.