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What's Old Is New Again: Pertussis

Caitlin Naureckas Li1, Kathryn M Edwards2, Sheldon L Kaplan3

  • 1Division of Infectious Diseases, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Pediatrics
|October 2, 2025
PubMed

Insights

Pertussis (whooping cough) remains difficult to control despite vaccines, with rising cases impacting infants most severely. Maternal vaccination during pregnancy offers crucial protection for newborns against this serious respiratory illness.

Area of Science:

  • Infectious Diseases
  • Pediatrics
  • Vaccinology

Background:

  • Pertussis (whooping cough) incidence is increasing despite vaccine availability.
  • Factors contributing to rising pertussis include improved diagnostics, vaccine changes, and missed vaccinations.
  • Infants are most vulnerable to severe pertussis complications and mortality.

Purpose of the Study:

  • To highlight the challenges in controlling pertussis.
  • To emphasize the importance of maternal immunization for infant protection.
  • To inform healthcare providers about pertussis presentation and management across age groups.

Main Methods:

  • Review of current pertussis epidemiology and control challenges.
  • Analysis of infant pertussis clinical presentation variations.
  • Discussion of vaccination strategies, including maternal vaccination and postexposure prophylaxis.

Main Results:

  • Pertussis control is hampered by diagnostic, vaccine, and vaccination access issues.
  • Infant pertussis presentation differs from adult stages.
  • Maternal immunization during pregnancy is a key protective strategy for infants.

Conclusions:

  • Understanding diverse clinical presentations is vital for prompt diagnosis and treatment.
  • Healthcare providers play a critical role in vaccination counseling for pregnant women and families.
  • Effective pertussis management requires a multi-faceted approach including vaccination and informed clinical practice.

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