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Fatal hepatic failure following accidental tramadol overdose
M B Loughrey1, C M Loughrey, S Johnston
1Department of Pathology, Belfast City Hospital, Lisburn Road, BT9 7AD Belfast, UK.
Forensic Science International
|July 10, 2003
Abstract:
A case of fatal overdose of tramadol is described, occurring in a 67-year-old man with painful rib fractures who accidentally ingested more than the recommended daily dose. The mode of death was acute liver failure due to fulminant hepatic necrosis. Post-mortem toxicology was negative apart from revealing a blood tramadol concentration well above the normal therapeutic range. This is the first report of fatal tramadol ingestion occurring in a therapeutic setting and also the first tramadol-related death where the mechanism was liver failure.