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Synthesis and biological evaluation of gambierol analogues
Haruhiko Fuwa1, Noriko Kainuma, Masayuki Satake
1Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Bioorganic & Medicinal Chemistry Letters
|July 11, 2003
Abstract:
Gambierol is a polycyclic ether toxin, isolated as a toxic constituent from the marine dinoflagellate Gambierdiscus toxicus. We describe here the synthesis and biological evaluation of structural analogues of gambierol. The present preliminary structure-activity relationship studies clearly indicate that the H ring functionality and the unsaturated side chain of gambierol are crucial for its potent toxicity.