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Related Experiment Videos

Advanced penile carcinoma.

Daniel J Culkin1, Tomasz M Beer

  • 1Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, USA.

The Journal of Urology
|July 11, 2003
PubMed
Summary
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Penile carcinoma, though rare, can be effectively managed with tailored lymphadenectomy and multimodal therapy including chemotherapy and radiation. Advances in staging and treatment have improved survival for advanced penile cancer.

Area of Science:

  • Oncology
  • Urology

Background:

  • Penile carcinoma is an uncommon malignancy in the US, accounting for 0.4% of male cancers.
  • Advanced penile cancer (30% of cases) presents a significant management challenge.
  • Improved understanding of disease natural history and staging has enhanced survival and reduced treatment morbidity.

Purpose of the Study:

  • To provide an overview of surgical, chemotherapeutic, and radiation treatments for advanced penile carcinoma.
  • To offer guidelines for patient selection in advanced penile cancer management.
  • To review current data on the etiology, epidemiology, staging, and treatment of penile cancer.

Main Methods:

  • A comprehensive literature review was conducted on advanced penile carcinoma.
  • The review encompassed etiology, epidemiology, natural history, staging, and treatment modalities.

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  • Available data on surgical, chemotherapeutic, and radiation treatments were analyzed.

    • Main Results:

    • Penile carcinoma staging is facilitated by nodal pathway spread, with prognosis correlating to nodal status and grade (TNM classification recommended).
    • Tailored lymphadenectomy has reduced morbidity and improved outcomes, though controversies remain regarding cN0 disease and pelvic lymphadenectomy.
    • Chemotherapy (cisplatin, bleomycin, methotrexate) and combination regimens show modest activity; radiation with other modalities is also active.

    Conclusions:

    • Effective locoregional treatment strategies have been developed based on the defined natural history of penile carcinoma.
    • Penile carcinoma is sensitive to radiation and specific chemotherapeutic agents.
    • Multimodal therapy and international clinical trials are crucial for advancing the standard of care in advanced penile cancer.