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[Proliferating cell nuclear antigen expression in recurrent aphthous ulcer and its significance]
Peng Sun1, Xiao-bing Fu, Wei Chen
1Department of Stomatology, 304th Hospital of People's Liberation Army, Beijing 100037, China.
Abstract
Objective:
To explore the expression changes of proliferating cell nuclear antigen (PCNA) in oral normal mucosa and recurrent aphthous ulcers(RAU).
Methods:
The expression intensity and distribution of PCNA were examined with immunohistochemistry method in 15 cases of recurrent oral aphthous and normal oral mucosa.
Results:
In RAU, there was large amount of inflamed cells. In normal oral mucosa, the expression intensity of PCNA was significant higher than that in oral aphthous (P<0.05).
Conclusion:
The inhibition of epidermal cells proliferation in RAU may be one of the mechanisms which one involved in RAU formation.