[Controlled ovarian hyperstimulation (COH) and management of low-responder cases (HOO)]

This paper will review the various stimulation protocols that have been attempted to improve results in low responders. Strategies have ranged from simple increasing the dose of exogenous gonadotropins, the use of adjunctive agents such as GnRH analogues and growth hormone, aromatase inhibitors and low dose aspirin. Improvements in overall responsiveness have been shown for some patients. In spite of this fact, the incremental improvement in results have generally been quite small.