[The relationship between vulvar micropapillomatosis and HPV-infection]

The etiology and the clinical significance of vulvar papillomatosis are still controversial. In order to study the relationship between micropapillomatosis labialis with some types of HPV infection we examined 60 patients with colposcopic characteristics of vulvar papillomatosis. Vulvar biopsies were taken for histological examination and for in situ hybridisation. 20 patients with vulvodynia without pathological findings in the region of the vulva served as a control group. Histological evidence for HPV infection were discovered in 50 patients /83.33%/ with vulvar papillomatosis, while 3 patients /5%/ were positive for HPV-DMA. These results show the rare relationship between the vestibular papillomatosis and HPV-infection. According to our study the physicians must be very cautious when treating these lesions, by positive histological results. The colposcopy is of fundamental importance for accurate diagnosis of vestibular papillomatosis and for successful treatment.