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Updated: Aug 15, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Functional consequences of the glycophenotype of squamous epithelia--practical employment
K Smetana1, J Plzák, B Dvoránková
1Charles University, 1st Faculty of Medicine, Institute of Anatomy, Prague, Czech Republic. Ksmet@1fl.cuni.cz
Abstract:
Squamous epithelia represent a morphologically and differentiation-dependent stratified tissue. The stem cells are located in the bulge region of hair follicles or in the basal layer of interfollicular epidermis and in the limbus of the cornea. This article summarizes the data about the glycobiological aspects of squamous epithelia cell differentiation under physiological as well as pathological conditions in relation to the function of this epithelial tissue. The entries about the LC, Merkel cells and melanocytes are also mentioned. The employment of the described data in the diagnostics of carcinomas derived from this type of epithelium as well as in the cell therapy of skin defects are shown.
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