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Updated: Sep 23, 2026
Aqueous Humor as a Liquid Biopsy for Retinoblastoma: Clear Corneal Paracentesis and Genomic Analysis
Published on: September 7, 2021
Detection of oncogenic human papillomavirus in sporadic retinoblastoma
M A Palazzi1, J A Yunes, I A Cardinalli
1Boldrini Children's Centre, Rua Décio de Almeida Filho 421, Campinas 13084-710, São Paulo, Brazil. palazzi@lexxa.com.br
Purpose:
To investigate the presence of human papillomavirus (HPV) DNA in tumour tissue from patients with unilateral retinoblastoma.
Methods:
Samples of paraffin-embedded tumour tissue from 43 children with unilateral retinoblastoma were collected to investigate the presence of HPV DNA using polymerase chain reaction (PCR) and dot blot hybridization.
Results:
Oncogenic HPV DNA types 16 and 35 were detected in 12 (27.9%) of 43 tumour specimens. A higher frequency of differentiated tumours (63.3%) was observed among the HPV-positive tumours.
Conclusions:
Future studies are necessary to demonstrate an association between HPV and sporadic retinoblastoma.
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