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The pathogenesis and diagnosis of foot-and-mouth disease

S Alexandersen1, Z Zhang, A I Donaldson

  • 1Pirbright Laboratory, Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey GU24 ONF, UK.

Journal of Comparative Pathology
|July 16, 2003
PubMed

Insights

This review details the pathogenesis of foot-and-mouth disease (FMD), covering viral, cellular, and whole-animal perspectives. It highlights advancements in understanding FMD immunity and control strategies.

Area of Science:

  • Veterinary Virology
  • Immunology
  • Epidemiology

Background:

  • Foot-and-mouth disease (FMD) remains a significant threat to livestock globally.
  • Understanding FMD pathogenesis is crucial for effective disease management and control.
  • Previous research has explored various aspects of FMD, but a comprehensive review integrating recent findings is needed.

Purpose of the Study:

  • To synthesize current knowledge on the pathogenesis of foot-and-mouth disease (FMD).
  • To integrate findings from field and experimental studies across multiple biological levels.
  • To highlight progress in FMD understanding concerning diagnosis and control.

Main Methods:

  • Comprehensive literature review of field and experimental studies on FMD.
  • Analysis of research data from viral, cellular, organ, and whole-animal levels.
  • Inclusion of studies on immune response and carrier states in FMD.

Main Results:

  • Detailed review of FMD pathogenesis from molecular to herd levels.
  • Discussion of the host-pathogen interactions and disease progression.
  • Integration of immune responses and the establishment of carrier states.

Conclusions:

  • Significant progress has been made in understanding FMD pathogenesis.
  • This knowledge is directly applicable to improving FMD diagnosis and control strategies.
  • Continued research integrating diverse study levels is essential for future FMD management.

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