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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Immunization in tumor prevention

Guido Forni1, Claudia Curcio, Michela Spadaro

  • 1Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Italy. guido.forni@unito.it

International Immunopharmacology
|July 16, 2003
PubMed

Insights

Activating immunity can prevent tumors, especially when targeting oncogenic growth factor receptors like Her-2/neu. This approach was successfully demonstrated in preventing mammary carcinomas in mice.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Prevention

Background:

  • Emerging data suggest the immune system can be harnessed for tumor prevention.
  • The immune environment in early-stage cancer is often intact and not tolerant to tumor antigens.
  • Oncogenic growth factor receptors represent viable targets for cancer immunoprevention.

Purpose of the Study:

  • To explore the potential of immune system activation for tumor prevention.
  • To investigate oncogenic growth factor receptors as targets for immunoprevention.
  • To summarize evidence supporting the immunoprevention of mammary carcinomas using Her-2/neu transgenic mouse models.

Main Methods:

  • Review of experimental data on cancer immunity and prevention.
  • Analysis of oncogenic growth factor receptors as tumor antigens.
  • Case study of Her-2/neu transgenic mice for mammary carcinoma prevention.

Main Results:

  • Experimental data support the activation of immunity for tumor prevention.
  • Her-2/neu transgenic mice demonstrated successful prevention of mammary carcinomas.
  • The Her-2/neu gene product serves as an effective antigen for preventive treatments.

Conclusions:

  • Immune system activation is a promising strategy for cancer prevention.
  • Targeting oncogenic growth factor receptors, such as Her-2/neu, is a valid approach for immunoprevention.
  • Further research into Her-2/neu antigen properties and immune responses is warranted.

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