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Chemokine induction by HIV-1: recruitment to the cause
1Department of Infectious Diseases and Microbiology, University of Pittsburgh, Graduate School of Public Health, 606 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, USA. reinhar@pitt.edu <reinhar@pitt.edu>
Abstract:
Immunomodulation frequently occurs during viral infections; the mechanisms of which are continually being defined at the cellular and tissue levels. Recently, a study of the effects of HIV-1 on dendritic cells (DCs) identified inflammatory chemokines as highly upregulated during HIV-1 infection and during viral Tat expression in monocyte-derived DCs. It is becoming increasingly clear that HIV-1 has evolved multiple strategies to ensure the maintenance of a local pool of susceptible cells for additional rounds of virus replication.